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中文摘要: 目的：评价紫蛇消瘤断经汤对肝旺肾虚型围绝经期子宫肌瘤伴月经过多患者月经量及生活质量的改善作用。 方法：收集符合纳入标准的患者62例,随机分为2组,每组31例。治疗组予紫蛇消瘤断经汤加减治疗,对照组口服宫血宁胶囊,均连续治疗3个月经周期。比较两组患者用药前后的经量(PBAC评分),并观察子宫和肌瘤体积、中医证候评分及生活质量评分的变化情况。 结果：①治疗后两组PBAC评分均较治疗前显著改善(P<0.05)；②治疗后两组患者子宫及肌瘤体积与治疗前比较均无明显改变(P>0.05)；③治疗组在改善中医全身相关证候疗效方面显著优于对照组(P<0.05)；④治疗组生活质量评分与治疗前比较有显著提高,其中对活力(VT)、精神健康(MH)及精神健康总评(PCS)的疗效均显著优于对照组(P<0.05)。 结论：紫蛇消瘤断经汤加减治疗肝旺肾虚型围绝经期子宫肌瘤伴月经过多,能显著减少月经出血量,改善中医证候,提高生活质量,并对子宫肌瘤的生长具有一定抑制作用。
Abstract: Objective:To assess the improving effects of Zishe Xiaoliu Duanjing Decoction on the menstrual volume and quality of life in patients of perimenopausal uterine myoma with menorrhagia of syndrome of liver hyperactivity and kidney deficiency. Methods:62 patients who met the inclusion criteria were randomly divided into 2 groups,31 cases in each group. The treatment group was treated with modified Zishe Xiaoliu Duanjing Decoction,and the control group was treated with Gongxuening Capsule,with a course of 3 menstrual cycles. The menstrual blood volume [pictorial blood loss assessment chart(PBAC) score] was compared in both groups before and after treatment,and the changes on the uterine and myoma volume,TCM syndrome score and quality of life(SF-36 score) were observed. Results:①After treatment,the PBAC score was significantly decreased in both groups(P<0.05).②Compared with before treatment,no obvious changes on the uterine and myoma volume were observed in both groups after treatment(P>0.05).③The improvement on TCM systemic syndrome in the treatment group was significantly better than that in the control group(P<0.05).④Compared with treatment before,the SF-36 scores of the treatment group were significantly increased after treatment,and the effects on vitality(VT),mental health(MH)and physical component summary(PCS)in the treatment group were significantly better than those in the control group(P<0.05). Conclusion:Modified Zishe Xiaoliu Duanjing Decoction can be used in the treatment of perimenopausal uterine myoma with menorrhagia of syndrome of liver hyperactivity and kidney deficiency,which can significantly reduce the menstrual bleeding,improve the TCM syndromes,enhance the quality of life,and shows a certain inhibitory effect on the growth of uterine myoma.
keywords: uterine myoma Zishe Xiaoliu Duanjing Decoction perimenopausal period menorrhagia syndrome of liver hyperactivity and kidney deficiency
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