###
DOI:
:2018,32(3):33-37
本文二维码信息
码上扫一扫!
益气养阴活血法对糖尿病合并高血压患者ANP、Angptl2、PAI-1的影响
李中南,马超,马淑红,邢艳阳,邢宇婷,窦德梅
(安徽中医药大学第一附属医院(安徽合肥230031))
Effects of therapy of benefiting qi and nourishing yin and activating blood circulation on ANP,Angptl2 and PAI-1 in diabetic patients with hypertension
LI Zhongnan,MA Chao,MA Shuhong,XING Yanyang,XING Yuting,DOU Demei
(First Affiliated Hospital of Anhui University of Traditional Chinese Medicine,Hefei 230031,China)
摘要
图/表
参考文献
相似文献
本文已被:浏览 2918次   下载 1454
    
中文摘要:   目的:观察具有益气养阴活血作用的丹蛭降糖胶囊(DJC)对糖尿病合并高血压患者血清心房钠尿肽(ANP)、血管生成素样蛋白2(Angptl2)、血浆纤溶酶原激活物抑制剂-1(PAI-1)水平的影响。  方法:纳入84例2型糖尿病合并高血压患者,随机分为治疗组42例和对照组42例。对照组患者予常规降压、降糖西药治疗,治疗组患者在常规西药治疗基础上加服丹蛭降糖胶囊,治疗周期均为12周。比较两组患者的中医症状积分及中医证候疗效,监测患者的SBP、DBP水平,检测患者的FPG、2 h PG、HbAlc及ANP、Angptl2、PAI-1水平。  结果:①治疗后,对照组的中医证候疗效总有效率为75.61%,治疗组为92.50%,治疗组疗效优于对照组(P<0.01)。②治疗后,治疗组患者的倦怠乏力、头痛眩晕、五心烦热、腰膝酸软、耳鸣心悸症状积分均下降(P<0.05,P<0.01),对照组患者仅耳鸣心悸症状积分下降(P<0.05),且治疗组患者的头痛眩晕、五心烦热、腰膝酸软、耳鸣心悸症状积分低于对照组(P<0.05,P<0.01)。③治疗后,两组患者的血清ANP、Angptl2、PAI-1水平较治疗前均明显降低(P<0.01),且治疗组患者的血清ANP、Angptl2、PAI-1水平均低于对照组(P<0.01,P<0.05)。④=4\*GB3治疗后,两组患者的SBP、DBP、FPG、2h PG及HbAlc水平较治疗前均明显降低(P<0.01),且治疗组患者的DBP、FPG水平低于对照组(P<0.05)。  结论:具有益气养阴活血作用的丹蛭降糖胶囊结合常规西药较单纯采用常规西药能够更好地改善2型糖尿病合并高血压患者的临床症状,调节血压、血糖,其作用机制可能与下调ANP、Angptl2、PAI-1的高表达相关。
Abstract:  Objective:To observe the effects of Danzhi Jiangtang Capsule that with effects of benefiting qi and nourishing yin and activating blood circulation on the serum levels of atrial natriuretic peptide(ANP),angiopoietin like protein 2(Angptl2)and plasminogen activator inhibitor-1(PAI-1)in diabetic patients with hypertension.   Methods:84 patients with type 2 diabetes mellitus and hypertension were randomly divided into the treatment group(n=42) and control group(n=42). The control group was treated with routine antihypertensive and hypoglycemic western medicine,and the treatment group was treated with Danzhi Jiangtang Capsule on the basis of conventional western medicine. The treatment course was 12 weeks in both groups. The TCM symptom scores and TCM syndrome efficacy were compared between the two groups,the levels of systolic blood pressure(SBP)and diastolic blood pressure(DBP)were monitored,and the levels of FPG,2h PG,HbAlc,ANP,Angptl2,and PAI-1 were detected.   Results:①After treatment,the total effective rates of TCM syndromes were 75.61% in the control group and 92.50% in the treatment group. The efficacy of the treatment group was significantly better than that of the control group(P<0.01). ②After treatment,the symptom scores of fatigue,headache and dizziness,dysphoria with feverish sensation in chest,palms and soles,soreness and weakness of waist and knees,tinnitus and palpitation were all decreased in the treatment group(P<0.05,P<0.01),the symptom score of tinnitus and palpitation was decreased in the control group(P<0.05). The scores of headache and dizziness,dysphoria with feverish sensation in chest,palms and soles,soreness and weakness of waist and knees,tinnitus and palpitation in the treatment group were lower than those in the control group(P<0.05,P<0.01). ③After treatment,the serum levels of ANP,Angptl2 and PAI-1 were obviously decreased in both groups(P<0.01),and the serum levels of ANP,Angptl2 and PAI-1 in the treatment group were lower than those in the control group(P<0.05,P<0.01). ④After treatment,the levels of SBP,DBP,FPG,2h PG and HbAlc were obviously decreased in both groups(P<0.01),and the DBP and FPG levels in the treatment group were lower than those in the control group(P<0.05).   Conclusion:Compared with western medicine treatment alone,Danzhi Jiangtang Capsule with effects of benefiting qi and nourishing yin and activating blood circulation combined with routine western medicine can better improve the clinical symptoms of type 2 diabetic patients with hypertension,and regulate blood pressure and blood glucose. Its mechanism may be related to the down-regulation on high expressions of ANP,Angptl2,and PAI-1.
文章编号:     中图分类号:    文献标志码:
基金项目:国家中医临床研究基地业务建设科研专项项目(JDZX2012004) [
引用文本: