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DOI:
:2017,(5):95-101
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四君子汤及加味方治疗恶性肿瘤的临床及基础研究进展
禹雯琦1,孙珏2,周诣3,杜锦芳1,石晓兰2
(1.上海中医药大学附属普陀医院(上海200062) ;2.上海中医药大学附属普陀医院中医肿瘤科(上海200062) ;3.上海中医药大学附属普陀医院教育科(上海200062))
Clinical and Fundamental Research Review of Sijunzi Decoction and Its Modified Recipes in the Treatment of Malignant Tumor
YU Wen-qi1, SUN Jue2, ZHUO Yi3, DU Jin-fang1, SHI Xiao-lan2
(1.Putuo Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai,200062;2.Oncology Department of Chinese Medicine,Putuo Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai,200062;3.Department of Education,Putuo Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai,200062)
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投稿时间:2017-06-15    
中文摘要: 四君子汤为补脾益气的经典方,亦是临床治疗恶性肿瘤的常用中药复方,目前有许多关于四君子汤及加味方在临床抗肿瘤及作用机制的研究和发现。临床研究方面,主要报道了对恶性肿瘤的防治作用及减轻化疗毒副反应、提高恶性肿瘤患者免疫功能、降低对化疗耐药的作用;基础研究方面,多从预防肿瘤发生、抑制肿瘤生长,以及促进肿瘤细胞凋亡、抑制肿瘤细胞转移、提高荷瘤动物免疫功能、缓解肿瘤恶病质等方面进行研究。
Abstract:As the classical prescription of invigorating spleen and replenishing qi,Sijunzi Decoction is also commonly used in the clinical treatment of malignant tumor. At present,there are a lot of researches and findings on the anti-tumor effects and mechanism of Sijunzi Decoction and its modified recipes. In clinical research,it has mainly reported its prevention and treatment for malignant tumors as well as the effects such as alleviating the toxic and side reactions of chemotherapy, improving the immune function of patients with malignant tumor and reducing the drug resistance to chemotherapy. In fundamental research,it has focused on its mechanisms such as preventing tumor formation,inhibiting tumor growth,promoting tumor cells apoptosis,suppressing tumor cells metastasis,improving the immune function of tumor bearing animals and relieving the cancer cachexia.
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基金项目:上海市卫计委科研基金项目(201640073);上海市普陀区卫生系统自主创新科研基金资助项目(2014-PT-ZD-006)
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